Human gametes and embryos cultured in vitro are extremely sensitive to oscilations in temperature, humidity, light expoosure, contaminats and phusical trauma. As such, reproductive laboratiories(RL) shall meeet several requirements with regard to design, constructive materials, equipment, illumination, temperature and humidity, safety, air quality control and monitoring, making them unique environments in biomedical sciences. Several reports suggest that toxicants(e.g., bacteria, particulate matter, dust and chemicals(voltaile oraganic compounds[VOCs])) may impact fertilization and embryo development. Although the need of specific technical requirements relating to air quality in IVF have been extensively debated, most practitioners acknowledge that more rigorous laboratory management is better pracrice and minimum standards towards air quality should be implemented^8^12.it is still a matter of debeat how high the standards for lavoratory air quality should be set, but animal experiments suggest that embryo development improve by cultivation embryos in cleanroom environments^13.
In humans, it has been demonstrated that cultivating embryos in cleanroom facilities is not detrimental to fertilization and embryo development^5.^7.^14.On the contrary, results of theaforementioned studies suggest that strict control of air quality conditions inside the embryology laboratory may optimize reproductive outcomes. Further more, regulatory agencies in many countries have issued directives which include specific requirements for air quality standards for embryology laboratories^15.^16. These documents take into accountthe permises of the "precautionary principle" to safeguard public health in the prevention of transmission of infectious diseases via tranplanted tissues and cells The precautionary principle is used where measures are needed in the face of a possible danger to human health where scientific data do not permit a complete evaluation of the risk. Air quality control is achieved by using air filtration systems, which are designed to both reduce particulates in air and to decrease VOC levels